› 7s9d

Electron Microscopy
4.6Å resolution

Cryo-EM Structure of dolphin Prestin: Intermediate state

Released:
DOI: 10.2210/pdb7s9d/pdb
PDB entry 7s9d coloured by chain, front view.
PDB entry 7s9d coloured by chain, side view.
PDB entry 7s9d coloured by chain, top view.
Source organism: Tursiops truncatus
Primary publication:
The conformational cycle of prestin underlies outer-hair cell electromotility.
Bavi N, Clark MD, Contreras GF, Shen R, Reddy BG, Milewski W, Perozo E
Nature 600 553-558 (2021)
PMID: 34695838
Related structures: EMD-24933

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prestin Chains: A, B
Molecule details ›
Chains: A, B
Length: 741 amino acids
Theoretical weight: 80.97 KDa
Source organism: Tursiops truncatus
Expression system: Homo sapiens
UniProt:
  • Canonical: D7PC76 (Residues: 1-741; Coverage: 100%)
Gene name: SLC26A5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-24933
Expression system: Homo sapiens

Quick links

Citations

7 review citations

New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility.
Puthenveetil et al. (2022)
6 more

1 mention without citation

Residue-level error detection in cryoelectron microscopy models.
Reggiano et al. (2023)