› 7she

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human GPR158

Released:
DOI: 10.2210/pdb7she/pdb
PDB entry 7she coloured by chain, front view.
PDB entry 7she coloured by chain, side view.
PDB entry 7she coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.
Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA
Science 375 86-91 (2022)
PMID: 34793198
Related structures: EMD-25125

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glycine receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 781 amino acids
Theoretical weight: 88.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5T848 (Residues: 1-775; Coverage: 63%)
Gene names: GPR158, KIAA1136
Sequence domains: 7 transmembrane sweet-taste receptor of 3 GCPR

Ligands and Environments

3 bound ligands:
Ligand PEE 1 x PEE
Ligand EIJ 1 x EIJ
Ligand CLR 22 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-25125
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Mass spectrometry of intact membrane proteins: shifting towards a more native-like context.
Oluwole et al. (2023)
3 more

2 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
1 more