› 7shm

Electron Microscopy
3.14Å resolution

Cryo-EM structure of ATP-bound human peroxisomal fatty acid transporter ABCD1

Released:
DOI: 10.2210/pdb7shm/pdb
PDB entry 7shm coloured by chain, front view.
PDB entry 7shm coloured by chain, side view.
PDB entry 7shm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Wang R, Qin Y, Li X
Cell Res 32 214-217 (2022)
PMID: 34754073
Related structures: EMD-25130

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family D member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 753 amino acids
Theoretical weight: 84.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P33897 (Residues: 2-745; Coverage: 100%)
Gene names: ABCD1, ALD
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.14Å
Relevant EMDB volumes: EMD-25130
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Sun et al. (2022)
2 more

3 mentions without citation

Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Chen et al. (2022)
2 more