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› 7sku

X-ray diffraction
2.12Å resolution

Nipah virus matrix protein in complex with PI(4,5)P2

Released:
DOI: 10.2210/pdb7sku/pdb
Model geometry
Fit model/data
PDB entry 7sku coloured by chain, front view.
PDB entry 7sku coloured by chain, side view.
PDB entry 7sku coloured by chain, top view.
Source organism: Henipavirus nipahense
Primary publication:
Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization.
Norris MJ, Husby ML, Kiosses WB, Yin J, Saxena R, Rennick LJ, Heiner A, Harkins SS, Pokhrel R, Schendel SL, Hastie KM, Landeras-Bueno S, Salie ZL, Lee B, Chapagain PP, Maisner A, Duprex WP, Stahelin RV, Saphire EO
OpenAccess logo Sci Adv 8 eabn1440 (2022)
PMID: 35857835

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 393 amino acids
Theoretical weight: 43.96 KDa
Source organism: Henipavirus nipahense
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9IK90 (Residues: 2-352; Coverage: 100%)
Gene name: M
Sequence domains: Paramyxoviridae matrix protein N-terminal domain

Ligands and Environments

2 bound ligands:
Ligand PIO 2 x PIO
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 70.114Å b: 96.471Å c: 119.972Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.264
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications.
Feng et al. (2023)
4 other articles

1 mention without citation

Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads.
Yang et al. (2023)