› 7slv

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed: 
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Pantetheinase Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 53.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O95497 (Residues: 22-483; Coverage: 94%)
Gene name: VNN1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 2 x NAG
Ligand BMA 3 x BMA
Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 2 x NAG
Ligand BMA 4 x BMA
3 bound ligands:
Ligand NAG 2 x NAG
Ligand 9TC 1 x 9TC
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 64.656Å b: 111.511Å c: 147.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.223
Expression system: Cricetulus griseus

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