7sp1

Electron Microscopy
3.4Å resolution

RNA-induced tau amyloid fibril

Released:
Source organisms:
Related structures: EMD-25364

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero heptadecamer (preferred)
PDBe Complex ID:
PDB-CPX-145396 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat
RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 10 nucleotides
Theoretical weight: 3.25 KDa
Source organism: Mus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-25364
Expression system: Escherichia coli