› 7sr5

X-ray diffraction
2.35Å resolution

Single chain trimer HLA-A*02:01 (Y108C, A163C) with Wilms tumor protein peptide RMFPNAPYL

Released:
DOI: 10.2210/pdb7sr5/pdb
Model geometry
Fit model/data
PDB entry 7sr5 coloured by chain, front view.
PDB entry 7sr5 coloured by chain, side view.
PDB entry 7sr5 coloured by chain, top view.
Source organisms:
Primary publication:
Effects of HLA single chain trimer design on peptide presentation and stability.
Finton KAK, Rupert PB, Friend DJ, Dinca A, Lovelace ES, Buerger M, Rusnac DV, Foote-McNabb U, Chour W, Heath JR, Campbell JS, Pierce RH, Strong RK
OpenAccess logo Front Immunol 14 1170462 (2023)
PMID: 37207206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233099 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-2-microglobulin; Ig-like domain-containing protein; Wilms tumor protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 424 amino acids
Theoretical weight: 47.68 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P19544 (Residues: 126-134; Coverage: 2%)
  • Canonical: P16213 (Residues: 21-119; Coverage: 100%)
  • Canonical: A0A6S7XV52 (Residues: 25-299; Coverage: 81%)
Gene names: B2M, HLA-A, WT1
Sequence domains:
VHH Chains: B, D
Molecule details ›
Chains: B, D
Length: 116 amino acids
Theoretical weight: 12.54 KDa
Source organism: Lama glama
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P41212
Unit cell:
a: 117.476Å b: 117.476Å c: 261.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.248
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E.
Brackenridge et al. (2024)
1 more

1 mention without citation

Effects of HLA single chain trimer design on peptide presentation and stability.
Finton et al. (2023)