› 7srk

X-ray diffraction
2.5Å resolution

Single chain trimer HLA-A*24:02 (Y108C, A163C) with 8mer peptide YPPVPETF

Released:
DOI: 10.2210/pdb7srk/pdb
PDB entry 7srk coloured by chain, front view.
PDB entry 7srk coloured by chain, side view.
PDB entry 7srk coloured by chain, top view.
Source organisms:
Primary publication:
Effects of HLA single chain trimer design on peptide presentation and stability.
Finton KAK, Rupert PB, Friend DJ, Dinca A, Lovelace ES, Buerger M, Rusnac DV, Foote-McNabb U, Chour W, Heath JR, Campbell JS, Pierce RH, Strong RK
Front Immunol 14 1170462 (2023)
PMID: 37207206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233133 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-2-microglobulin; Ig-like domain-containing protein; RPA-related protein RADX Chains: A, C
Molecule details ›
Chains: A, C
Length: 423 amino acids
Theoretical weight: 47.35 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NSI4 (Residues: 307-319; Coverage: 1%)
  • Canonical: P16213 (Residues: 21-119; Coverage: 100%)
  • Canonical: F6IR24 (Residues: 25-299; Coverage: 88%)
Gene names: B2M, CXorf57, HLA-A, RADX
Sequence domains:
VHH Chains: B, D
Molecule details ›
Chains: B, D
Length: 116 amino acids
Theoretical weight: 12.54 KDa
Source organism: Lama glama
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-X
Spacegroup: P212121
Unit cell:
a: 69.924Å b: 76.072Å c: 226.974Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.26
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Effects of HLA single chain trimer design on peptide presentation and stability.
Finton et al. (2023)