› 7std

X-ray diffraction
1.8Å resolution

SCYTALONE DEHYDRATASE PLUS INHIBITOR 4

Released:
DOI: 10.2210/pdb7std/pdb
PDB entry 7std coloured by chain, front view.
PDB entry 7std coloured by chain, side view.
PDB entry 7std coloured by chain, top view.
Source organism: Pyricularia grisea
Primary publication:
High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
Wawrzak Z, Sandalova T, Steffens JJ, Basarab GS, Lundqvist T, Lindqvist Y, Jordan DB
Proteins 35 425-39 (1999)
PMID: 10382670

Function and Biology Details

Reaction catalysed: 
Scytalone = 1,3,8-trihydroxynaphthalene + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-157440 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Scytalone dehydratase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 164 amino acids
Theoretical weight: 19.38 KDa
Source organism: Pyricularia grisea
Expression system: Escherichia coli
UniProt:
  • Canonical: P56221 (Residues: 10-172; Coverage: 95%)
Gene names: MGG_05059, SDH1
Sequence domains: Scytalone dehydratase
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand CRP 3 x CRP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: I222
Unit cell:
a: 80.57Å b: 91.06Å c: 161.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.229
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Biosynthesis of fungal melanins and their importance for human pathogenic fungi.
Langfelder et al. (2003)
1 more

4 mentions without citation

Halogen bonds in biological molecules.
Auffinger et al. (2004)
3 more