› 7sto

Electron Microscopy
3.15Å resolution

Chitin Synthase 2 from Candida albicans bound to polyoxin D

Released:
DOI: 10.2210/pdb7sto/pdb
PDB entry 7sto coloured by chain, front view.
PDB entry 7sto coloured by chain, side view.
PDB entry 7sto coloured by chain, top view.
Source organism: Candida albicans
Primary publication:
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.
Ren Z, Chhetri A, Guan Z, Suo Y, Yokoyama K, Lee SY
Nat Struct Mol Biol (2022)
PMID: 35788183
Related structures: EMD-25435

Function and Biology Details

Reaction catalysed: 
UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151768 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitin synthase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1039 amino acids
Theoretical weight: 119.3 KDa
Source organism: Candida albicans
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30572 (Residues: 1-1009; Coverage: 100%)
Gene name: CHS2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 3PE 8 x 3PE
Ligand BJ9 2 x BJ9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-25435
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Chitin Synthesis in Yeast: A Matter of Trafficking.
Sánchez et al. (2022)
1 more

1 mention without citation

Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.
Ren et al. (2022)