› 7svn

X-ray diffraction
2.78Å resolution

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 9 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 869 amino acids
Theoretical weight: 99.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86TI2 (Residues: 1-863; Coverage: 100%)
Gene names: DPP9, DPRP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CW8 4 x CW8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 119.789Å b: 117.439Å c: 163.455Å
α: 90° β: 105.49° γ: 90°
R-values:
R R work R free
0.268 0.267 0.349
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution?
Deng et al. (2023)
3 other articles