› 7t2c

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-134735 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
T cell receptor alpha chain constant Chain: D
Molecule details ›
Chain: D
Length: 204 amino acids
Theoretical weight: 22.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
T cell receptor beta constant 1 Chain: E
Molecule details ›
Chain: E
Length: 249 amino acids
Theoretical weight: 27.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
HLA class II histocompatibility antigen, DP alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P20036 (Residues: 32-212; Coverage: 78%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Sequence domains:
HLA class II histocompatibility antigen, DP beta 1 chain Chain: B
Molecule details ›
Chain: B
Length: 188 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04440 (Residues: 30-217; Coverage: 82%)
Gene names: HLA-DP1B, HLA-DPB1
Sequence domains:
Pneumolysin Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Streptococcus pneumoniae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q04IN8 (Residues: 429-441; Coverage: 3%)
Gene names: SPD_1726, ply

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand EDO 1 x EDO
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 91.933Å b: 77.712Å c: 153.684Å
α: 90° β: 96.71° γ: 90°
R-values:
R R work R free
0.213 0.211 0.257
Expression systems:
  • Escherichia coli BL21(DE3)
  • Trichoplusia ni

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