› 7t2d

X-ray diffraction
3.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-134735 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (8 distinct):
HLA class II histocompatibility antigen, DP alpha 1 chain Chains: A, F, K, P
Molecule details ›
Chains: A, F, K, P
Length: 181 amino acids
Theoretical weight: 20.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P20036 (Residues: 32-212; Coverage: 78%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Sequence domains:
HLA class II histocompatibility antigen, DP beta 1 chain Chains: B, G, L, Q
Molecule details ›
Chains: B, G, L, Q
Length: 188 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04440 (Residues: 30-217; Coverage: 82%)
Gene names: HLA-DP1B, HLA-DPB1
Sequence domains:
Pneumolysin Chains: C, H, M, R
Molecule details ›
Chains: C, H, M, R
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Streptococcus pneumoniae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q04IN8 (Residues: 429-441; Coverage: 3%)
Gene names: SPD_1726, ply
T cell receptor alpha chain constant Chains: D, I, N, S
Molecule details ›
Chains: D, I, N, S
Length: 207 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
T cell receptor beta constant 1 Chains: E, J, O, T
Molecule details ›
Chains: E, J, O, T
Length: 243 amino acids
Theoretical weight: 27.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21212
Unit cell:
a: 159.709Å b: 193.57Å c: 236.799Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.271
Expression systems:
  • Trichoplusia ni
  • Escherichia coli BL21(DE3)

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