› 7t47

X-ray diffraction
1.27Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-164; Coverage: 87%)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family

Ligands and Environments

6 bound ligands:
Ligand 6IC 1 x 6IC
Ligand GCP 1 x GCP
Ligand GDP 1 x GDP
Ligand GOL 1 x GOL
Ligand ACT 1 x ACT
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 40.311Å b: 50.579Å c: 92.903Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.172
Expression system: Escherichia coli

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