› 7t5m

X-ray diffraction
1.67Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-158327 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 278 amino acids
Theoretical weight: 32.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q861F7 (Residues: 1-278; Coverage: 82%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, D
Molecule details ›
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Interleukin-27 receptor subunit alpha Chains: E, F
Molecule details ›
Chains: E, F
Length: 20 amino acids
Theoretical weight: 2.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6UWB1 (Residues: 617-636; Coverage: 3%)
Gene names: CRL1, IL27RA, TCCR, UNQ296/PRO336, WSX1

Ligands and Environments

2 bound ligands:
Ligand TRS 1 x TRS
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Unit cell:
a: 70.178Å b: 99.903Å c: 135.464Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.208
Expression systems:
  • Escherichia coli
  • Not provided

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