› 7t74

Electron Microscopy
3.35Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-225824 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (11 distinct):
HIV Envelope ApexGT2 gp120 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 504 amino acids
Theoretical weight: 56.12 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
HIV Envelope ApexGT2 gp41 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 162 amino acids
Theoretical weight: 18.31 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
RM20A3 Fab Heavy Chain Chains: I, K, M
RM20A3 Fab Light Chain Chains: G, J, N
PCT64.35S Fab Light Chain Chain: L
PCT64.35S Fab Heavy Chain Chain: H

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 42 x NAG
1 modified residue:
Ligand TYS 1 x TYS

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.35Å
Relevant EMDB volumes: EMD-25733
Expression system: Homo sapiens

Quick links

Citations

5 review citations

An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1.
Kumar et al. (2023)
4 more

1 mention without citation

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Willis et al. (2022)