› 7to7

X-ray diffraction
1.93Å resolution

BRD3-BD1 in complex with RaPID linear peptide 1xAcK.4XE (monoAcK.4xE)

Released:
DOI: 10.2210/pdb7to7/pdb
Model geometry
Fit model/data
PDB entry 7to7 coloured by chain, front view.
PDB entry 7to7 coloured by chain, side view.
PDB entry 7to7 coloured by chain, top view.
Source organisms:
Primary publication:
mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.
Low JKK, Patel K, Jones N, Solomon P, Norman A, Maxwell JWC, Pachl P, Matthews JM, Payne RJ, Passioura T, Suga H, Walport LJ, Mackay JP
OpenAccess logo J Biol Chem 299 105482 (2023)
PMID: 37992806

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168870 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 3 Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 128 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15059 (Residues: 25-147; Coverage: 17%)
Gene names: BRD3, KIAA0043, RING3L
Sequence domains: Bromodomain
1xAcK.4xE (monoAcK.4xE) Chains: C, F
Molecule details ›
Chains: C, F
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
1 modified residue:
Ligand ALY 2 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 41.862Å b: 99.277Å c: 120.608Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.251
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 citations in other articles

mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B.
Cremosnik et al. (2024)

1 mention without citation

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.
Low et al. (2023)