7tue

X-ray diffraction
3.1Å resolution

Crystal structure of Tapasin in complex with HLA-B*44:05 (T73C)

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-238515 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: D5H3J5 (Residues: 25-298; Coverage: 81%)
Gene name: HLA-B
Sequence domains:
Tapasin Chain: D
Molecule details ›
Chain: D
Length: 416 amino acids
Theoretical weight: 44.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15533 (Residues: 21-401; Coverage: 89%)
  • Best match: O15533-2 (Residues: 21-401)
Gene names: NGS17, TAPA, TAPBP
Sequence domains: Immunoglobulin C1-set domain
Beta-2-microglobulin Chain: B

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 116.866Å b: 116.866Å c: 131.141Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.298 0.286 0.309
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli