› 7tx8

X-ray diffraction
2.51Å resolution

Long form D7 protein from Anopheles darlingi with U46619 and serotonin bound

Released:
DOI: 10.2210/pdb7tx8/pdb
PDB entry 7tx8 coloured by chain, front view.
PDB entry 7tx8 coloured by chain, side view.
PDB entry 7tx8 coloured by chain, top view.
Source organism: Anopheles darlingi
Primary publication:
Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Alvarenga PH, Dias DR, Xu X, Francischetti IMB, Gittis AG, Arp G, Garboczi DN, Ribeiro JMC, Andersen JF
Insect Biochem Mol Biol 146 103785 (2022)
PMID: 35568118

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Long form salivary protein D7L2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 297 amino acids
Theoretical weight: 34.89 KDa
Source organism: Anopheles darlingi
Expression system: Escherichia coli
UniProt:
  • Canonical: B6DDQ8 (Residues: 21-317; Coverage: 100%)
Gene name: D7L2

Ligands and Environments

2 bound ligands:
Ligand SRO 4 x SRO
Ligand PUC 4 x PUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 98.06Å b: 98.06Å c: 273.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.218 0.266
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis.
Lu et al. (2023)

2 mentions without citation

An Overview of D7 Protein Structure and Physiological Roles in Blood-Feeding Nematocera.
Alvarenga et al. (2022)
1 more