› 7txz

Electron Microscopy
3.2Å resolution

Nipah Virus attachment (G) glycoprotein ectodomain in complex with nAH1.3 neutralizing antibody Fab fragment (local refinement of the distal region)

Released:
DOI: 10.2210/pdb7txz/pdb
PDB entry 7txz coloured by chain, front view.
PDB entry 7txz coloured by chain, side view.
PDB entry 7txz coloured by chain, top view.
Source organism: Mus sp.
Primary publication:
Architecture and antigenicity of the Nipah virus attachment glycoprotein.
Wang Z, Amaya M, Addetia A, Dang HV, Reggiano G, Yan L, Hickey AC, DiMaio F, Broder CC, Veesler D
Science 375 1373-1378 (2022)
PMID: 35239409
Related structures: EMD-26162

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-278838 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Glycoprotein G Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 539 amino acids
Theoretical weight: 60.36 KDa
UniProt:
  • Canonical: Q9IH62 (Residues: 70-601; Coverage: 88%)
Gene name: G
Sequence domains: Haemagglutinin-neuraminidase
nAH1.3 Fab heavy chain Chains: E, H
Molecule details ›
Chains: E, H
Length: 458 amino acids
Theoretical weight: 50.64 KDa
Source organism: Mus sp.
Expression system: Homo sapiens
nAH1.3 Fab light chain Chains: F, L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.2Å
Relevant EMDB volumes: EMD-26162
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Nipah Virus Disease: Epidemiological, Clinical, Diagnostic and Legislative Aspects of This Unpredictable Emerging Zoonosis.
Bruno et al. (2022)
7 more

7 mentions without citation

Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant.
Wang et al. (2022)
6 more