› 7u0f

Electron Microscopy
3.53Å resolution

HIV-1 Rev in complex with tubulin

Released:
DOI: 10.2210/pdb7u0f/pdb
PDB entry 7u0f coloured by chain, front view.
PDB entry 7u0f coloured by chain, side view.
PDB entry 7u0f coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev.
Eren E, Watts NR, Randazzo D, Palmer I, Sackett DL, Wingfield PT
Structure (2023)
PMID: 37572662
Related structures: EMD-26257

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 150-mer (preferred)
PDBe Complex ID:
PDB-CPX-227109 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tubulin alpha-1A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 451 amino acids
Theoretical weight: 50.12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02550 (Residues: 1-451; Coverage: 100%)
Gene name: TUBA1A
Sequence domains:
Tubulin beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 445 amino acids
Theoretical weight: 49.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02554 (Residues: 1-445; Coverage: 100%)
Sequence domains:
Protein Rev Chains: E, F, G, H, I, J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.53Å
Relevant EMDB volumes: EMD-26257
Expression system: Escherichia coli

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