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› 7u14

Electron Microscopy
4.5Å resolution

TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type C (case 8)

Released:
DOI: 10.2210/pdb7u14/pdb
PDB entry 7u14 coloured by chain, front view.
PDB entry 7u14 coloured by chain, side view.
PDB entry 7u14 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
Cell 185 1346-1355.e15 (2022)
PMID: 35247328
Related structures: EMD-26277

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein 106B Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 135 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NUM4 (Residues: 120-254; Coverage: 49%)
Gene name: TMEM106B
Sequence domains: TM106 protein C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.5Å
Relevant EMDB volumes: EMD-26277
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
14 more