7ucf

X-ray diffraction
4Å resolution

Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-226240 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (20 distinct):
Transmembrane protein gp41 Chain: B
Molecule details ›
Chain: B
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
BG24 Fab heavy chain Chain: D
Molecule details ›
Chain: D
Length: 234 amino acids
Theoretical weight: 25.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BG24 light chain Chain: E
Molecule details ›
Chain: E
Length: 205 amino acids
Theoretical weight: 21.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 501 amino acids
Theoretical weight: 55.77 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 29-505; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
10-1074 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 243 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
10-1074 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, FUC, BMA
Carbohydrate polymer : NEW Components: MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: R3
Unit cell:
a: 208.958Å b: 208.958Å c: 155.914Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.246 0.277
Expression system: Homo sapiens