› 7ukf

Electron Microscopy
3.02Å resolution

Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region

Released:
DOI: 10.2210/pdb7ukf/pdb
PDB entry 7ukf coloured by chain, front view.
PDB entry 7ukf coloured by chain, side view.
PDB entry 7ukf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes.
Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
Mol Cell (2022)
PMID: 35597238
Related structures: EMD-26579

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A-type voltage-gated potassium channel KCND2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 524 amino acids
Theoretical weight: 59.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZV8 (Residues: 1-524; Coverage: 83%)
Gene names: KCND2, KIAA1044
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand K 4 x K
Ligand HG 1 x HG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.02Å
Relevant EMDB volumes: EMD-26579
Expression system: Homo sapiens

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Citations

2 review citations

Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6).
Malloy et al. (2022)
1 more

1 mention without citation

Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes.
Ye et al. (2022)