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7ukr

X-ray diffraction
2.5Å resolution

Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the SOS1:KRAS Protein-Protein Interaction

Released:
Model geometry
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Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-170560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Son of sevenless homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 487 amino acids
Theoretical weight: 57.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07889 (Residues: 564-1049; Coverage: 37%)
Gene name: SOS1
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 77.719Å b: 148.22Å c: 52.418Å
α: 90° β: 108.269° γ: 90°
R-values:
R R work R free
0.237 0.234 0.282
Expression system: Escherichia coli