Function and Biology Details
Reactions catalysed:
GTP + H(2)O = GDP + phosphate
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Leucine-rich repeat, typical subtype
- Leucine-rich repeat
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Leucine-rich repeat domain superfamily
- Small GTPase
- Metallo-dependent phosphatase-like
- P-loop containing nucleoside triphosphate hydrolase
- Calcineurin-like phosphoesterase domain, ApaH type
3 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127156 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ras-related protein M-Ras
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 20.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ras family
Length: 183 amino acids
Theoretical weight: 20.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O14807 (Residues: 1-182; Coverage: 88%)
Sequence domains: Ras family
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Molecule details ›
Chain: B
Length: 331 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 331 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P62136 (Residues: 1-330; Coverage: 100%)
Sequence domains:
Leucine-rich repeat protein SHOC-2
Molecule details ›
Chain: C
Length: 583 amino acids
Theoretical weight: 65.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Leucine rich repeat
Length: 583 amino acids
Theoretical weight: 65.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UQ13 (Residues: 1-582; Coverage: 100%)
Sequence domains: Leucine rich repeat
