› 7usm

Electron Microscopy
2.7Å resolution

Integrin alphaM/beta2 ectodomain

Released:
DOI: 10.2210/pdb7usm/pdb
PDB entry 7usm coloured by chain, front view.
PDB entry 7usm coloured by chain, side view.
PDB entry 7usm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS
OpenAccess logo Cell Rep 40 111196 (2022)
PMID: 35977491
Related structures: EMD-26739

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138495 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Integrin alpha-M Chain: A
Molecule details ›
Chain: A
Length: 1162 amino acids
Theoretical weight: 128.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P11215 (Residues: 17-1104; Coverage: 96%)
  • Best match: P11215-2 (Residues: 17-1105)
Gene names: CD11B, CR3A, ITGAM
Sequence domains:
Integrin beta-2 Chain: B
Molecule details ›
Chain: B
Length: 730 amino acids
Theoretical weight: 80.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-699; Coverage: 91%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 4 x CA
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.7Å
Relevant EMDB volumes: EMD-26739
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Outsmarting Pathogens with Antibody Engineering.
Qerqez et al. (2023)
1 more

3 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
2 more