Function and Biology Details
Reaction catalysed:
PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- tRNA intron endonuclease, catalytic domain-like
- tRNA intron endonuclease, catalytic domain-like superfamily
- tRNA endonuclease-like domain superfamily
- tRNA-splicing endonuclease, subunit Sen54, N-terminal
- tRNA-splicing endonuclease, subunit Sen54
- tRNA intron endonuclease, N-terminal
- tRNA-splicing endonuclease, SEN2 subunit
- tRNA-splicing endonuclease
3 more domains
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
tRNA-splicing endonuclease and tRNA (preferred)
PDBe Complex ID:
PDB-CPX-290164 (preferred)
Entry contents:
4 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (5 distinct):
tRNA-splicing endonuclease subunit Sen34
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 37.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: tRNA intron endonuclease, catalytic C-terminal domain
Length: 352 amino acids
Theoretical weight: 37.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9BSV6 (Residues: 1-309; Coverage: 100%)
Sequence domains: tRNA intron endonuclease, catalytic C-terminal domain
tRNA-splicing endonuclease subunit Sen15
Molecule details ›
Chain: B
Length: 183 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Sen15 protein
Length: 183 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8WW01 (Residues: 1-171; Coverage: 100%)
Sequence domains: Sen15 protein
tRNA-splicing endonuclease subunit Sen2
tRNA-splicing endonuclease subunit Sen54
