› 7v0s

Electron Microscopy
2.5Å resolution

Local refinement of RhAG/CE trimer, class 1 of erythrocyte ankyrin-1 complex

Released:
DOI: 10.2210/pdb7v0s/pdb
PDB entry 7v0s coloured by chain, front view.
PDB entry 7v0s coloured by chain, side view.
PDB entry 7v0s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture of the human erythrocyte ankyrin-1 complex.
Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Calì T, Clarke OB
Nat Struct Mol Biol 29 706-718 (2022)
PMID: 35835865
Related structures: EMD-26949

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-147655 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Blood group Rh(CE) polypeptide Chain: K
Molecule details ›
Chain: K
Length: 417 amino acids
Theoretical weight: 45.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18577 (Residues: 1-417; Coverage: 100%)
Gene names: RHC, RHCE, RHE
Sequence domains: Ammonium Transporter Family
Ammonium transporter Rh type A Chains: L, Q
Molecule details ›
Chains: L, Q
Length: 409 amino acids
Theoretical weight: 44.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02094 (Residues: 1-409; Coverage: 100%)
Gene names: RH50, RHAG
Sequence domains: Ammonium Transporter Family
Ankyrin-1 Chain: J

Ligands and Environments

2 bound ligands:
Ligand CLR 2 x CLR
Ligand AJP 1 x AJP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.5Å
Relevant EMDB volumes: EMD-26949

Quick links

Citations

1 review citation

Alloimmune hemolytic disease of the fetus and newborn: genetics, structure, and function of the commonly involved erythrocyte antigens.
Christensen et al. (2023)
18 other articles

1 mention without citation

Architecture of the human erythrocyte ankyrin-1 complex.
Vallese et al. (2022)