› 7v74

Electron Microscopy
3Å resolution

Thermostabilized human prestin in complex with sulfate

Released:
DOI: 10.2210/pdb7v74/pdb
PDB entry 7v74 coloured by chain, front view.
PDB entry 7v74 coloured by chain, side view.
PDB entry 7v74 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.
Futamata H, Fukuda M, Umeda R, Yamashita K, Tomita A, Takahashi S, Shikakura T, Hayashi S, Kusakizako T, Nishizawa T, Homma K, Nureki O
Nat Commun 13 6208 (2022)
PMID: 36266333
Related structures: EMD-31758

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
prestin Chain: A
Molecule details ›
Chain: A
Length: 753 amino acids
Theoretical weight: 82.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand CLR 2 x CLR
Ligand LBN 8 x LBN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-31758
Expression system: Homo sapiens

Quick links

Citations

1 review citation

SLC26 Anion Transporters.
Geertsma et al. (2024)
5 other articles