› 7vnu

X-ray diffraction
1.95Å resolution

Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein

Released:
DOI: 10.2210/pdb7vnu/pdb
Model geometry
Fit model/data
PDB entry 7vnu coloured by chain, front view.
PDB entry 7vnu coloured by chain, side view.
PDB entry 7vnu coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2.
Ni X, Han Y, Zhou R, Zhou Y, Lei J
OpenAccess logo Commun Biol 6 193 (2023)
PMID: 36806252

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 131 amino acids
Theoretical weight: 14.32 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC9 (Residues: 47-174; Coverage: 31%)
Gene name: N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 58.711Å b: 91.412Å c: 96.122Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.226
Expression system: Escherichia coli

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Citations

4 mentions without citation

Overview of Nucleocapsid-Targeting Vaccines against COVID-19.
Rak et al. (2023)
3 more