› 7vrd

X-ray diffraction
1.7Å resolution

Crystal structure of Enolase1 from Candida albicans complexed with 2'-phosphoglyceric acid sodium

Released:
DOI: 10.2210/pdb7vrd/pdb
PDB entry 7vrd coloured by chain, front view.
PDB entry 7vrd coloured by chain, side view.
PDB entry 7vrd coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis.
Li L, Lu H, Zhang X, Whiteway M, Wu H, Tan S, Zang J, Tian S, Zhen C, Meng X, Li W, Zhang D, Zhang M, Jiang Y
Microbiol Spectr 10 e0208522 (2022)
PMID: 35900099

Function and Biology Details

Reaction catalysed: 
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151769 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enolase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 439 amino acids
Theoretical weight: 47.16 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli
UniProt:
  • Canonical: P30575 (Residues: 2-440; Coverage: 100%)
Gene names: CAALFM_C108500CA, CaO19.395, CaO19.8025, ENO1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 6 x MG
Ligand 2PG 2 x 2PG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 264.264Å b: 61.848Å c: 111.752Å
α: 90° β: 109.8° γ: 90°
R-values:
R R work R free
0.173 0.172 0.197
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum from Lentinus brumalis.
Jeong et al. (2023)
4 more

2 mentions without citation

Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis.
Li et al. (2022)
1 more