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› 7w9k

Electron Microscopy
2.2Å resolution

Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution

Released:
DOI: 10.2210/pdb7w9k/pdb
PDB entry 7w9k coloured by chain, front view.
PDB entry 7w9k coloured by chain, side view.
PDB entry 7w9k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV.
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep 39 110735 (2022)
PMID: 35476982
Related structures: EMD-32368

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130219 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2031 amino acids
Theoretical weight: 231.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15858 (Residues: 1-1988; Coverage: 100%)
Gene names: NENA, SCN9A
Sequence domains:
Sodium channel regulatory subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain
Sodium channel regulatory subunit beta-2 Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
8 bound ligands:
Ligand NAG 5 x NAG
Ligand P5S 3 x P5S
Ligand Y01 6 x Y01
Ligand 9Z9 1 x 9Z9
Ligand NA 1 x NA
Ligand LPE 15 x LPE
Ligand 1PW 1 x 1PW
Ligand PCW 5 x PCW
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.2Å
Relevant EMDB volumes: EMD-32368
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Structural biology and molecular pharmacology of voltage-gated ion channels.
Huang et al. (2024)
6 more

20 mentions without citation

A structural atlas of druggable sites on Nav channels.
Li et al. (2024)
19 more