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› 7wi6

Electron Microscopy
3.71Å resolution

Cryo-EM structure of LY341495/NAM-bound mGlu3

Released:
DOI: 10.2210/pdb7wi6/pdb
PDB entry 7wi6 coloured by chain, front view.
PDB entry 7wi6 coloured by chain, side view.
PDB entry 7wi6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the activation of metabotropic glutamate receptor 3.
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J
OpenAccess logo Cell Res 32 695-698 (2022)
PMID: 35236939
Related structures: EMD-32526

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 887 amino acids
Theoretical weight: 100.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14832 (Residues: 23-879; Coverage: 100%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand Z99 2 x Z99
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.71Å
Relevant EMDB volumes: EMD-32526
Expression system: Spodoptera frugiperda

Quick links

Citations

9 citation in other articles

Kinetic fingerprinting of metabotropic glutamate receptors.
Kukaj et al. (2023)
8 more

3 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
2 more