› 7wp6

Electron Microscopy
3.81Å resolution

Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies

Released:
DOI: 10.2210/pdb7wp6/pdb
PDB entry 7wp6 coloured by chain, front view.
PDB entry 7wp6 coloured by chain, side view.
PDB entry 7wp6 coloured by chain, top view.
Source organisms:
Primary publication:
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
OpenAccess logo Cell Host Microbe 30 1732-1744.e7 (2022)
PMID: 36323313
Related structures: EMD-32676

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225224 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (8 distinct):
36H6 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 119 amino acids
Theoretical weight: 13.13 KDa
Source organism: Mus musculus
83H7 light chain Chain: C
Molecule details ›
Chain: C
Length: 104 amino acids
Theoretical weight: 11.43 KDa
Source organism: Mus musculus
83H7 heavy chain Chain: D
Spike protein S1 Chain: F
85F7 heavy chain Chain: H
36H6 light chain Chain: I
85F7 light chain Chain: L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.81Å
Relevant EMDB volumes: EMD-32676
Expression system: Cricetulus griseus

Quick links

Citations

3 review citations

Challenges and developments in universal vaccine design against SARS-CoV-2 variants.
Zhao et al. (2022)
2 more

1 mention without citation

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Wu et al. (2022)