› 7x5u

X-ray diffraction
1.6Å resolution

Crystal structure of AtHPPD-diketonitrile complex

Released:
DOI: 10.2210/pdb7x5u/pdb
Model geometry
Fit model/data
PDB entry 7x5u coloured by chain, front view.
PDB entry 7x5u coloured by chain, side view.
PDB entry 7x5u coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules
Dong J, Dong J, Yu XH, Yan YC, Nan JX, He B, Ye BQ, Yang WC, Lin HY, Yang GF
Adv Agrochem (2022)

Function and Biology Details

Reaction catalysed: 
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxyphenylpyruvate dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 417 amino acids
Theoretical weight: 45.95 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P93836 (Residues: 33-445; Coverage: 93%)
Gene names: At1g06570, F12K11.9, HPD, PDS1
Sequence domains: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

Ligands and Environments

3 bound ligands:
Ligand CO 1 x CO
Ligand 9R6 1 x 9R6
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 76.66Å b: 83.852Å c: 62.052Å
α: 90° β: 100.17° γ: 90°
R-values:
R R work R free
0.188 0.187 0.208
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links