› 7x79

X-ray diffraction
1.8Å resolution

The crystal structure of human Calpain-1 protease core in complex with 14b

Released:
DOI: 10.2210/pdb7x79/pdb
Model geometry
Fit model/data
PDB entry 7x79 coloured by chain, front view.
PDB entry 7x79 coloured by chain, side view.
PDB entry 7x79 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhao Y, Zhao J, Shao M, Yang H, Rao Z

Function and Biology Details

Reaction catalysed: 
Broad endopeptidase specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calpain-1 catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 714 amino acids
Theoretical weight: 81.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07384 (Residues: 1-714; Coverage: 100%)
Gene names: CANPL1, CAPN1, PIG30
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 89K 1 x 89K
Ligand H2S 1 x H2S
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 50.203Å b: 64.07Å c: 99.576Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.202
Expression system: Escherichia coli BL21(DE3)

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