› 7x7s

Solution NMR

Solution structure of human adenylate kinase 1 (hAK1)

Released:
DOI: 10.2210/pdb7x7s/pdb
PDB entry 7x7s coloured by chain, ensemble of 20 models, front view.
PDB entry 7x7s coloured by chain, ensemble of 20 models, side view.
PDB entry 7x7s coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
ADP-Induced Conformational Transition of Human Adenylate Kinase 1 Is Triggered by Suppressing Internal Motion of α3α4 and α7α8 Fragments on the ps-ns Timescale.
Guo C, Zhang H, Lin W, Chen H, Chang T, Wu Z, Yu J, Lin D
OpenAccess logo Biomolecules 12 (2022)
PMID: 35625598

Function and Biology Details

Reactions catalysed: 
ATP + AMP = 2 ADP
ATP + nucleoside phosphate = ADP + nucleoside diphosphate
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase isoenzyme 1 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00568 (Residues: 1-194; Coverage: 100%)
Gene name: AK1
Sequence domains: Adenylate kinase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

ADP-Induced Conformational Transition of Human Adenylate Kinase 1 Is Triggered by Suppressing Internal Motion of α3α4 and α7α8 Fragments on the ps-ns Timescale.
Guo et al. (2022)