› 7xbi

X-ray diffraction
2.16Å resolution

The crystal structure of human TrkA kinase bound to the inhibitor

Released:
DOI: 10.2210/pdb7xbi/pdb
Model geometry
Fit model/data
PDB entry 7xbi coloured by chain, front view.
PDB entry 7xbi coloured by chain, side view.
PDB entry 7xbi coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wu CY, Wang G, Ouyang L

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 35.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04629 (Residues: 485-795; Coverage: 41%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand CVY 1 x CVY
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3112
Unit cell:
a: 52.01Å b: 52.01Å c: 229.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.188 0.246
Expression system: Spodoptera frugiperda

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