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› 7xho

Electron Microscopy
3.29Å resolution

Structure of human inner kinetochore CCAN complex

Released:
DOI: 10.2210/pdb7xho/pdb
PDB entry 7xho coloured by chain, front view.
PDB entry 7xho coloured by chain, side view.
PDB entry 7xho coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human CCAN complex assembled onto DNA.
Tian T, Chen L, Dou Z, Yang Z, Gao X, Yuan X, Wang C, Liu R, Shen Z, Gui P, Teng M, Meng X, Hill DL, Li L, Zhang X, Liu X, Sun L, Zang J, Yao X
OpenAccess logo Cell Discov 8 90 (2022)
PMID: 36085283
Related structures: EMD-33197

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptadecamer (preferred)
PDBe Complex ID:
PDB-CPX-108749 (preferred)
Entry contents:
16 distinct polypeptide molecules
Macromolecules (16 distinct):
Centromere protein C Chains: C, c
Molecule details ›
Chains: C, c
Length: 943 amino acids
Theoretical weight: 107.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q03188 (Residues: 1-943; Coverage: 100%)
Gene names: CENPC, CENPC1, ICEN7
Sequence domains:
Centromere protein H Chain: H
Molecule details ›
Chain: H
Length: 247 amino acids
Theoretical weight: 28.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9H3R5 (Residues: 1-247; Coverage: 100%)
Gene names: CENPH, ICEN35
Sequence domains: Centromere protein H (CENP-H)
Centromere protein I Chain: I
Centromere protein K Chain: K
Centromere protein L Chain: L
Centromere protein M Chain: M
Centromere protein N Chain: N
Centromere protein O Chain: O
Centromere protein P Chain: P
Centromere protein Q Chain: Q
Centromere protein S Chain: S
Centromere protein T Chain: T
Centromere protein W Chain: W
Centromere protein X Chain: X
Centromere protein R Chain: R
Centromere protein U Chain: U

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.29Å
Relevant EMDB volumes: EMD-33197
Expression systems:
  • Spodoptera frugiperda
  • Trichoplusia ni

Quick links

Citations

8 citation in other articles

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Dendooven et al. (2023)
7 more

1 mention without citation

Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.
Liu et al. (2023)