› 7xnm

X-ray diffraction
3.58Å resolution

Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex

Released:
DOI: 10.2210/pdb7xnm/pdb
PDB entry 7xnm coloured by chain, front view.
PDB entry 7xnm coloured by chain, side view.
PDB entry 7xnm coloured by chain, top view.
Source organisms:
Entry authors: Li WY, Cao MJ

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215968 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 728 amino acids
Theoretical weight: 84.43 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P22411 (Residues: 39-766; Coverage: 95%)
Gene names: CD26, DPP4
Sequence domains:
ILE-LEU-ALA-PRO-PRO-GLU-ARG Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 796 Da
Source organism: Crassostrea gigas
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 257.34Å b: 75.617Å c: 121.679Å
α: 90° β: 110.199° γ: 90°
R-values:
R R work R free
0.229 0.223 0.299
Expression system: Not provided

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