› 7xqh

Electron Microscopy
3.8Å resolution

Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (GCN-TM1i conformation)

Released:
DOI: 10.2210/pdb7xqh/pdb
PDB entry 7xqh coloured by chain, front view.
PDB entry 7xqh coloured by chain, side view.
PDB entry 7xqh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM.
Lee HJ, Cha HJ, Jeong H, Lee SN, Lee CW, Kim M, Yoo J, Woo JS
OpenAccess logo Nat Commun 14 931 (2023)
PMID: 36805660
Related structures: EMD-33396

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148032 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction alpha-1 protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 257 amino acids
Theoretical weight: 29.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P17302 (Residues: 1-257; Coverage: 67%)
Gene names: GJA1, GJAL
Sequence domains: Connexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.8Å
Relevant EMDB volumes: EMD-33396
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Diversity in connexin biology.
Lucaciu et al. (2023)
1 more