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7xw2

Electron Microscopy
3.04Å resolution

Cryo-EM structure of human DICER-pre-miRNA in a dicing state

Released:
Source organism: Homo sapiens
Related structures: EMD-33489

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-194045 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Endoribonuclease Dicer Chain: A
Molecule details ›
Chain: A
Length: 1922 amino acids
Theoretical weight: 218.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UPY3 (Residues: 1-1922; Coverage: 100%)
Gene names: DICER, DICER1, HERNA, KIAA0928
Sequence domains:
RNA (73-MER) Chain: C
Molecule details ›
Chain: C
Length: 73 nucleotides
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.04Å
Relevant EMDB volumes: EMD-33489
Expression systems:
  • Homo sapiens
  • Not provided