› 7y1t

Electron Microscopy
3.24Å resolution

Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2

Released:
DOI: 10.2210/pdb7y1t/pdb
PDB entry 7y1t coloured by chain, front view.
PDB entry 7y1t coloured by chain, side view.
PDB entry 7y1t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8.
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
OpenAccess logo Nat Commun 13 4988 (2022)
PMID: 36008481
Related structures: EMD-33572

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134057 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-V heavy chain Chain: A
Molecule details ›
Chain: A
Length: 635 amino acids
Theoretical weight: 69.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 1-429, 430-625; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Integrin beta-8 Chain: B
Molecule details ›
Chain: B
Length: 477 amino acids
Theoretical weight: 53.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P26012 (Residues: 43-498; Coverage: 63%)
  • Best match: P26012-2 (Residues: 1-363)
Gene name: ITGB8
Sequence domains:
Transforming growth factor beta-1 proprotein Chain: D

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand NAG 5 x NAG
Ligand CA 5 x CA
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.24Å
Relevant EMDB volumes: EMD-33572
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy.
Li et al. (2023)
2 other articles