› 7y4b

X-ray diffraction
1.86Å resolution

Crystal structure of DUSP10 mutant_D59A

Released:
DOI: 10.2210/pdb7y4b/pdb
PDB entry 7y4b coloured by chain, front view.
PDB entry 7y4b coloured by chain, side view.
PDB entry 7y4b coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hu IC, Lyu PC

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 149 amino acids
Theoretical weight: 17.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9Y6W6 (Residues: 320-467; Coverage: 31%)
Gene names: DUSP10, MKP5
Sequence domains: Dual specificity phosphatase, catalytic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P1
Unit cell:
a: 40.23Å b: 41.584Å c: 56.826Å
α: 96.03° β: 100.44° γ: 117.45°
R-values:
R R work R free
0.188 0.184 0.23
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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