› 7y4f

X-ray diffraction
1.92Å resolution

bacterial DPP4

Released:
DOI: 10.2210/pdb7y4f/pdb
Model geometry
Fit model/data
PDB entry 7y4f coloured by chain, front view.
PDB entry 7y4f coloured by chain, side view.
PDB entry 7y4f coloured by chain, top view.
Source organism: Bacteroides thetaiotaomicron
Primary publication:
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Wang K, Zhang Z, Hang J, Liu J, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q, Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G, Gonzalez FJ, Lei X, Qiao J, Jiang C
Science 381 eadd5787 (2023)
PMID: 37535747

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase IV Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 736 amino acids
Theoretical weight: 84.19 KDa
Source organism: Bacteroides thetaiotaomicron
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q8A028 (Residues: 1-736; Coverage: 100%)
Gene name: BT_4193
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 95.8Å b: 148.857Å c: 137.125Å
α: 90° β: 104.02° γ: 90°
R-values:
R R work R free
0.169 0.168 0.193
Expression system: Escherichia coli K-12

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Citations

1 review citation

Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values.
Wang et al. (2023)
3 other articles