› 7y72

Electron Microscopy
4.03Å resolution

SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface)

Released:
DOI: 10.2210/pdb7y72/pdb
PDB entry 7y72 coloured by chain, front view.
PDB entry 7y72 coloured by chain, side view.
PDB entry 7y72 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor.
Chia WN, Tan CW, Tan AWK, Young B, Starr TN, Lopez E, Fibriansah G, Barr J, Cheng S, Yeoh AY, Yap WC, Lim BL, Ng TS, Sia WR, Zhu F, Chen S, Zhang J, Kwek MSS, Greaney AJ, Chen M, Au GG, Paradkar PN, Peiris M, Chung AW, Bloom JD, Lye D, Lok S, Wang LF
OpenAccess logo Sci Adv 9 eade3470 (2023)
PMID: 37494438
Related structures: EMD-33651

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225346 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, C
Molecule details ›
Chains: A, C
Length: 1198 amino acids
Theoretical weight: 132.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 16-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Fab E7 light chain Chain: P
Molecule details ›
Chain: P
Length: 219 amino acids
Theoretical weight: 23.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab E7 heavy chain Chain: O

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.03Å
Relevant EMDB volumes: EMD-33651
Expression system: Homo sapiens

Quick links

Citations

1 review citation

In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms.
Cankat et al. (2024)
1 other article