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› 7yhw

Electron Microscopy
3.09Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement)

Released:
DOI: 10.2210/pdb7yhw/pdb
PDB entry 7yhw coloured by chain, front view.
PDB entry 7yhw coloured by chain, side view.
PDB entry 7yhw coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun 14 4405 (2023)
PMID: 37479708
Related structures: EMD-33841

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-305555 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 596 amino acids
Theoretical weight: 69.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 195 amino acids
Theoretical weight: 22.05 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.09Å
Relevant EMDB volumes: EMD-33841
Expression system: Homo sapiens

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