7ys6

Electron Microscopy
3Å resolution

Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex

Released:
Source organisms:
Primary publication:
Structural insights into constitutive activity of 5-HT6 receptor.
OpenAccess logo Proc Natl Acad Sci U S A 120 e2209917120 (2023)
PMID: 36989299
Related structures: EMD-34073

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-250794 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
5-hydroxytryptamine receptor 6 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Insecta environmental sample
UniProt:
  • Canonical: P50406 (Residues: 24-345; Coverage: 69%)
Gene name: HTR6
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 357 amino acids
Theoretical weight: 39.39 KDa
Source organism: Homo sapiens
Expression system: Insecta environmental sample
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: D
scFv16 Chain: E
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: B

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution:
Relevant EMDB volumes: EMD-34073
Expression system: Insecta environmental sample