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› 7ytp

Electron Microscopy
2.77Å resolution

TLR7 in complex with an inhibitor

Released:
DOI: 10.2210/pdb7ytp/pdb
PDB entry 7ytp coloured by chain, front view.
PDB entry 7ytp coloured by chain, side view.
PDB entry 7ytp coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.
Ishizaka ST, Hawkins L, Chen Q, Tago F, Yagi T, Sakaniwa K, Zhang Z, Shimizu T, Shirato M
Eur J Pharmacol 957 175962 (2023)
PMID: 37544422
Related structures: EMD-34091

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
TIR domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 975 amino acids
Theoretical weight: 111.56 KDa
Source organism: Macaca mulatta
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: B3Y653 (Residues: 27-842; Coverage: 78%)
Gene name: TLR7
Sequence domains: Leucine rich repeat

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 10 x NAG
Ligand JRI 2 x JRI
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.77Å
Relevant EMDB volumes: EMD-34091
Expression system: Drosophila melanogaster

Quick links

Citations

2 review citations

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.
von Hofsten et al. (2024)
1 more